Penicillin g procaine
Bicillin C-r, Penicillin G Procaine (penicillin g procaine) is a small molecule pharmaceutical. Penicillin g procaine was first approved as Bicillin c-r on 1982-01-01. It is used to treat actinomycosis, anthrax, bacterial infections, bacterial skin diseases, and botulism amongst others in the USA.
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Commercial
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Penicillin g procaine (discontinued: Duracillin a.s, Penicillin g procaine, Pfizerpen-as)
CombinationsBicillin c-r (discontinued: Bicillin c-r)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Penicillin g benzathine
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Penicillin g procaine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| BICILLIN C-R | King Pharmaceuticals | N-050138 RX | 1982-01-01 | 1 products, RLD, RS |
| BICILLIN C-R 900/300 | King Pharmaceuticals | N-050138 RX | 1982-01-01 | 1 products, RLD, RS |
Show 1 discontinued
Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| bicillin c-r 900/300 | New Drug Application | 2024-06-03 |
| bicillin cr | New Drug Application | 2024-06-04 |
Indications
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Agency Specific
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Clinical
Clinical Trials
77 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Syphilis | D013587 | EFO_0007504 | A53.9 | 1 | 4 | 6 | 7 | 3 | 20 |
| Pneumonia | D011014 | EFO_0003106 | J18 | — | 1 | 3 | 1 | 2 | 6 |
| Infections | D007239 | EFO_0000544 | — | — | 1 | 2 | 2 | 1 | 6 |
| Sepsis | D018805 | EFO_0001420 | A41.9 | — | — | 2 | 1 | 2 | 5 |
| Hiv infections | D015658 | EFO_0000764 | B20 | — | 1 | 2 | 1 | 1 | 4 |
| Communicable diseases | D003141 | — | — | — | — | 1 | 2 | 1 | 4 |
| Hypersensitivity | D006967 | EFO_0003785 | T78.40 | — | 1 | — | 1 | 2 | 4 |
| Yaws | D015001 | EFO_0007548 | A66 | — | — | 2 | 1 | — | 3 |
| Bacteremia | D016470 | EFO_0003033 | R78.81 | — | — | — | 3 | — | 3 |
| Drug hypersensitivity | D004342 | EFO_0009482 | T88.7 | — | 1 | — | 1 | 1 | 3 |
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Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Neurosyphilis | D009494 | EFO_0007339 | A50.40 | — | — | 1 | — | 2 | 3 |
| Treponemal infections | D014211 | EFO_1001217 | — | — | — | 2 | — | — | 2 |
| Bacterial infections | D001424 | — | A49 | — | — | 1 | — | 1 | 2 |
| Neonatal sepsis | D000071074 | — | — | — | — | 1 | — | 1 | 2 |
| Toxemia | D014115 | — | — | — | — | 1 | — | 1 | 2 |
| Tuberculosis | D014376 | EFO_0000774 | A15-A19 | — | 1 | 1 | — | — | 1 |
| Cytomegalovirus infections | D003586 | EFO_0001062 | B25 | — | 1 | 1 | — | — | 1 |
| Malnutrition | D044342 | EFO_0008572 | E40-E46 | — | — | 1 | — | — | 1 |
| Microbial drug resistance | D004352 | — | — | — | — | 1 | — | — | 1 |
| Severe acute malnutrition | D000067011 | — | — | — | — | 1 | — | — | 1 |
Show 12 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Heart diseases | D006331 | EFO_0003777 | I51.9 | — | 2 | — | — | 2 | 4 |
| Rheumatic heart disease | D012214 | EFO_1001161 | I09.9 | — | 2 | — | — | 2 | 4 |
| Rheumatic diseases | D012216 | — | M79.0 | — | 2 | — | — | 1 | 3 |
| Urinary bladder neoplasms | D001749 | — | C67 | 2 | 1 | — | — | — | 3 |
| Non-muscle invasive bladder neoplasms | D000093284 | — | — | 2 | 1 | — | — | — | 3 |
| Psoriasis | D011565 | EFO_0000676 | L40 | — | 1 | — | — | 1 | 2 |
| Congenital syphilis | D013590 | EFO_0007219 | A50 | — | 1 | — | — | 1 | 2 |
| Covid-19 | D000086382 | — | U07.1 | — | 1 | — | — | — | 1 |
| Congenital abnormalities | D000013 | EFO_0003915 | Q89.9 | — | 1 | — | — | — | 1 |
| Lymphangioma | D008202 | — | D18.1 | — | 1 | — | — | — | 1 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 2 | — | — | — | — | 2 |
| Streptococcal infections | D013290 | EFO_1001476 | — | 1 | — | — | — | 1 | 2 |
| Pharyngitis | D010612 | — | R07.0 | 1 | — | — | — | 1 | 2 |
| Osteomyelitis | D010019 | EFO_0003102 | M86 | 1 | — | — | — | — | 1 |
| Bacterial vaginosis | D016585 | EFO_0003932 | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Critical illness | D016638 | — | — | — | — | — | — | 1 | 1 |
| Hiv seropositivity | D006679 | — | — | — | — | — | — | 1 | 1 |
| Hepatitis c | D006526 | — | B19.2 | — | — | — | — | 1 | 1 |
| Chronic hepatitis c | D019698 | EFO_0004220 | B18.2 | — | — | — | — | 1 | 1 |
| Hepatitis | D006505 | — | K75.9 | — | — | — | — | 1 | 1 |
| Hepatitis a | D006506 | EFO_0007305 | B15 | — | — | — | — | 1 | 1 |
| Psoriatic arthritis | D015535 | EFO_0003778 | L40.5 | — | — | — | — | 1 | 1 |
| Ulcerative colitis | D003093 | EFO_0000729 | K51 | — | — | — | — | 1 | 1 |
| Rheumatoid arthritis | D001172 | EFO_0000685 | M06.9 | — | — | — | — | 1 | 1 |
| Crohn disease | D003424 | EFO_0000384 | K50 | — | — | — | — | 1 | 1 |
Show 9 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Penicillin g procaine |
| INN | — |
| Description | Procaine benzylpenicillin also known as penicillin G procaine, is an antibiotic useful for the treatment of a number of bacterial infections. Specifically it is used for syphilis, anthrax, mouth infections, pneumonia, diphtheria, cellulitis, and animal bites. It is given by injection into a muscle.
|
| Classification | Small molecule |
| Drug class | local anesthetics; penicillins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O.CCN(CC)CCOC(=O)c1ccc(N)cc1.O |
Identifiers
| PDB | — |
| CAS-ID | 54-35-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1200936 |
| ChEBI ID | — |
| PubChem CID | 5903 |
| DrugBank | — |
| UNII ID | — |
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Safety
Black-box Warning
Black-box warning for: Bicillin c-r 900/300, Bicillin cr
Adverse Events
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503 adverse events reported
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