Penicillin g procaine
Bicillin C-r, Penicillin G Procaine (penicillin g procaine) is a small molecule pharmaceutical. Penicillin g procaine was first approved as Bicillin c-r on 1982-01-01. It is used to treat actinomycosis, anthrax, bacterial infections, bacterial skin diseases, and botulism amongst others in the USA.
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Commercial
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Penicillin g procaine (discontinued: Duracillin a.s, Penicillin g procaine, Pfizerpen-as)
CombinationsBicillin c-r (discontinued: Bicillin c-r)
Drug Products
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New Drug Application (NDA)
New Drug Application (NDA)
Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
Penicillin g benzathine
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Penicillin g procaine
Tradename | Company | Number | Date | Products |
|---|---|---|---|---|
| BICILLIN C-R | King Pharmaceuticals | N-050138 RX | 1982-01-01 | 1 products, RLD, RS |
| BICILLIN C-R 900/300 | King Pharmaceuticals | N-050138 RX | 1982-01-01 | 1 products, RLD, RS |
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| bicillin c-r 900/300 | New Drug Application | 2024-06-03 |
| bicillin cr | New Drug Application | 2024-06-04 |
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837 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Tonsillitis | D014069 | — | — | — | — | 1 | 1 | — | 2 |
| Sinusitis | D012852 | EFO_0007486 | J32 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Pneumonia | D011014 | EFO_0003106 | J18 | — | 1 | 1 | — | 2 | 4 |
| Bacterial pneumonia | D018410 | EFO_1001272 | J15.9 | — | 1 | 1 | — | — | 2 |
| Chronic bronchitis | D029481 | — | J42 | — | — | 1 | — | — | 1 |
| Bronchitis | D001991 | — | J40 | — | — | 1 | — | — | 1 |
| Acute disease | D000208 | — | — | — | — | 1 | — | — | 1 |
| Otitis media | D010033 | EFO_0004992 | H66.9 | — | — | 1 | — | — | 1 |
| Otitis | D010031 | — | — | — | — | 1 | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Healthy volunteers/patients | — | — | — | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Community-acquired pneumonia | D000098968 | — | — | — | — | — | — | 1 | 1 |
| Abscess | D000038 | EFO_0003030 | — | — | — | — | — | 1 | 1 |
| Peritonitis | D010538 | EFO_0008588 | K65 | — | — | — | — | 1 | 1 |
| Lung abscess | D008169 | EFO_1001362 | J85.2 | — | — | — | — | 1 | 1 |
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Penicillin g procaine |
| INN | — |
| Description | Procaine benzylpenicillin also known as penicillin G procaine, is an antibiotic useful for the treatment of a number of bacterial infections. Specifically it is used for syphilis, anthrax, mouth infections, pneumonia, diphtheria, cellulitis, and animal bites. It is given by injection into a muscle.
|
| Classification | Small molecule |
| Drug class | local anesthetics; penicillins |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(=O)O.CCN(CC)CCOC(=O)c1ccc(N)cc1.O |
Identifiers
| PDB | — |
| CAS-ID | 54-35-3 |
| RxCUI | — |
| ChEMBL ID | CHEMBL1200936 |
| ChEBI ID | — |
| PubChem CID | 5903 |
| DrugBank | — |
| UNII ID | — |
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Safety
Black-box Warning
Black-box warning for: Bicillin c-r 900/300, Bicillin cr
Adverse Events
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503 adverse events reported
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